Story in The Surge 2 about the ecological wasteland where the setting would be.
The Surge 2 Background
The Surge 2 takes place in a world that is destroying itself through ecological collapse. The environmental disasters are unprecedented, with rivers drying out and all sorts of wildlife dying out due to pollution. Humanity is concentrated in large cities that are struggling to sustain itself, and a large corporation named CREO's efforts to restore the planet by firing rockets full of nanobots into the atmosphere didn't turn out as expected. Unfortunately, those nanobots drove the city's inhabitants into a rage – causing them to go crazy and start killing each other.
Wraped up with Rogue Process, the Utopia Rocket was launched from CREO facility that located at outskirt Jericho City, exploded in the atmosphere. The nanite spawned and encountered CREO Flight 221 on its way to Jericho City. Part of the passengers decomposed by the nanite, most died in the crash, only three "survived": the protagonist, Jonah Guttenberg's 11 years old grandchild Athena, and a man named Henderson. Both the protagonist and Athena were infected by nanite. However, because of Athena's young undeveloped brain and similar genes with the nanite's creator, she had built an incredible connection with the swarm. She then revived the protagonist, for he/she helped with her little toy problem and struggled to save her from being swallowed by the swarm. As for Henderson, who helped by the protagonist among the accident, not only survived the crash, but also woke up in time before drowned, even got away before the A.I.D.(Assault Insurgent Disease) Response team reach there.
Long before the event, Matriarch Celeste run a cult at Port Nixon, the rising place of Jericho city, to seek a way of combining human and technology. Using her connection with Jonah Guttenberg to acquire nano-tech from CREO, the cult successed in reviving suitable zealots for a long time. After the air crash, her drug lord son Jonathan found Rogue Process at the crash site, but it's his big brother Eli who successfully connected with it/them. Driving by its desire to join the swarm, Eli used Rogue Process to hack the AI system of CREO Institute of Technology, H.A.R.O.L.D., in order to take use of Jonah Guttenberg's research.
As the Utopia swarm spread, a disease called Defrag that can turn patient into nanite appeared among the Jericho citizen. The A.I.D. Polaris research team build a lab around the Utopia crash site, they comfired that these nanite had no off-switch, however children's brain might adapted well to it. So they gathered children throughout the city, by telling parents it was to cure their kids' disease, by hiring unwitting soldier and The Hunter group to capture the rest. All these children were sent to Liang Wei Hospital at A.I.D. Command for experiments, used to connect and control the swarm. As for the Great Wall of Jericho that said to be built for containing the nanite, it's no use but only about politics and kickbacks.
Some times later, Athena awoke in a warehouse at Port Nixon. She sent a message to the A.I.D. Response team for help. They found her, but the nanite in her body started to grow aggressive so she tried to run, and some of the Spark cultists attacked the team among the chasing. Athena travelled through Port Nixon, Downtown, Underground, then Guideon's Rock, getting close to her grandfather at CREO Institute of Technology, but eventually captured by the Hunter group. While travelling through the city, she tried to create a nanite creature in order to rescue protagonist as her warrior, but failed in the first two times, leaving Delver Echo Alpha in underground and Gamma in downtown. The third attempt at Guideon's Rock was successful, so she sent the last Delver to Detention Center, woke the protagonist up from his/her two months' coma. That's when/where the main game starts.